TTR · GalNAc, SC
Vutrisiran (Amvuttra)
An approved siRNA therapeutic silencing TTR, indicated for hATTR polyneuropathy; ATTR-CM. This page lists what the siRNA Atlas corpus holds on Vutrisiran and links to each primary document.
Identity
- Generic name
- Vutrisiran
- Brand name
- Amvuttra
- Molecular target
- TTR
- Indication
- hATTR polyneuropathy; ATTR-CM
- Delivery
- GalNAc, SC
- FDA application
- NDA 215515
- Regulatory coverage
- FDA and EMA
Source documents in the corpus (5)
- FDAFDA prescribing information (current label)
- FDAFDA review
- FDAFDA pharmacology / toxicology review
- EMAEMA public assessment report (EPAR)
- EMAEMA product information (SmPC)
Every answer about Vutrisiran is drawn from these documents and the indexed literature, and cites the passage it used. Tables inside them are preserved, so numeric dosing, exposure and toxicology values stay searchable.
Ask the corpus about Vutrisiran
- →What is the approved dose and dosing interval of vutrisiran (Amvuttra)?
- →Describe the clinical pharmacology and ADME of vutrisiran.
- →What did the regulatory reviews conclude about the nonclinical safety of vutrisiran?
- →Summarise the pivotal trial evidence for vutrisiran.
- →How does vutrisiran silence TTR, and how long does the effect last?
Other approved siRNA therapeutics
Information here is drawn from public regulatory records for reference and research. It is not medical advice — verify any clinical or regulatory decision against the current label and assessment report linked above.